An unlikely circle of doctors, chemists, poets and political radicals formed a group round the maverick physician Thomas Beddoes. In the closing years of the eighteenth century, he founded the first modern medical institute, the Pneumatic Institute in Bristol. When he and its researchers discovered the mind-altering properties of nitrous oxide, or laughing gas, what was a pioneering public health initiative became a freewheeling exploration of consciousness.

Celebrated historian Mike Jay tells the story of Dr. Beddoes and his group of unorthodox experimenters. With the support of Erasmus Darwin and poets Robert Southey and Samuel Taylor Coleridge, a laboratory designed by James Watt and funded by Thomas Wedgwood, and the self-experimenting chemistry assistant Humphrey Davy, Beddoes precipitated a revolution in scientific investigation.

Free Radicals for the first time charts the intellectual ferment of the Institute and reveals its crucial influence-as the crucible of the Romantic movement, and the birthplace of modern drug culture.

“Richly detailed and frequently illuminating.”-Rhys Blakely, Times (UK)

“Excellent.”-Clare Bucknell, New Yorker

A New Yorker Best of the Week Pick

A provocative and original history of the scientists and writers, artists and philosophers who took drugs to explore the hidden regions of the mind

Until the twentieth century, scientists investigating the effects of drugs on the mind did so by experimenting on themselves. Vivid descriptions of drug experiences sparked insights across the mind sciences, pharmacology, medicine, and philosophy. Accounts in journals and literary fiction inspired a fascinated public to make their own experiments-in scientific demonstrations, on exotic travels, at literary salons, and in occult rituals.

But after 1900 drugs were increasingly viewed as a social problem, and the long tradition of self-experimentation began to disappear.

From Sigmund Freud’s experiments with cocaine to William James’s epiphany on nitrous oxide, Mike Jay brilliantly recovers a lost intellectual tradition of drug-taking that fed the birth of psychology, the discovery of the unconscious, and the emergence of modernism. Today, as we embrace novel cognitive enhancers and psychedelics, the experiments of the original psychonauts reveal the deep influence of mind-altering drugs on Western science, philosophy, and culture.

Colonel Despard was the last person to be sentenced to hanging, drawing and quartering in Britain – for high treason, an alleged plot to kill the king. His execution on 21st February 1803 was witnessed by twenty thousand hushed onlookers. Their silence was ominous, for few believed he was guilty. His death would tear apart a Britain still reeling from the impact of the French Revolution and the Napoleonic Wars.

But who was Edward Marcus Despard? Was he, as his comrade-in-arms on the Spanish Main Lord Nelson believed, an outstanding British army officer of unimpeachable honour, courage and patriotism? Or, as the white slave-owners of the Caribbean claimed, a traitor not only to his nation but to his race, who had married a local woman and championed the rights of freed slaves?

And when Despard returned to London to answer these allegations, did he commit himself to the cause of political reform in Britain’s best interest? Or did he join a shadowy international terrorist conspiracy dedicated to the murder of George III and the overthrow of the state? Despard’s contested fate marked the sensational climax to a British revolution that never happened, but it also presaged the birth of modern democracy.

‘Compelling, absorbing and wide-ranging . . . Jay weaves a complex variety of themes, many with overtly topical resonances, into Despard’s journey from hero to traitor’
Sunday Times