‘Mary Roach offers a fascinating tour of the wonderful world of regenerative medicine.’  TIME, The Most Anticipated Books of Fall 2025

Our bodies regenerate at a remarkable rate – our skin replaces itself every month, our blood every four. You can remove ninety per cent of a liver and it’ll still grow back to its original size (please do not try this at home).

Others – the brain, the heart, the eyes – are more complicated. These stay with us for life. So what do we do when they break down? For centuries, medicine has searched for answers – sculpting noses from brass, borrowing skin from frogs and hearts from pigs and crafting eye parts from jet canopies. And as technology has grown ever more ingenious, so have our solutions.

In Replaceable You, Mary Roach sets sail on the uncharted waters of regenerative medicine, exploring the remarkable advances and difficult questions prompted by the human body’s failings:

• When and how does a person decide they’d be better off with a prosthetic than their existing limb?

• Is there a sensitive way to harvest tissue and bones from the deceased?

• Which animals might be the best organ donors?

Through interviews with patients, physicians, pathologists, engineers and scientists, Roach immerses readers in the wondrous, improbable and surreal quest to build a new you.

‘Addictively readable… Don’t miss it.’ Deborah Blum, author of  The Poisoner’s Handbook

‘A must read.’ Siddhartha Mukherjee, bestselling author of  The Emperor of All Maladies

What does it take to create a new medicine? The trajectory from laboratory to your neighbourhood pharmacy rarely runs smooth. Drug hunting demands radical leaps of imagination, the expertise of many? and a hefty dollop of luck. Unsurprisingly, ‘eureka’ moments come few and far between – but, when they do, they change lives.

Charting the discovery of eight revolutionary drugs, Dr William Pao cuts to the innovative heart of biomedical research and celebrates the tireless work of the scientists, doctors, patients and families fighting for better medical care. For each of these medicines, whether a potentially life-saving new treatment for cancer, or something as commonplace as paracetamol, there stands a cast of characters and a wealth of stories. Documenting these fascinating journeys, Breakthrough grants a privileged, behind-the-scenes look at the medicines that improve – and very often save – our lives.

Foreword by Nobel Prize-Winner Harold Varmus

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‘Utterly compelling.’ Dame Kate Bingham, author of  The Long Shot

‘A celebration of medical innovation.’ Guardian

‘Captivating… An essential read.’  Art Levinson, former CEO of Genentech

We often hear about the dark side of the pharmaceutical industry – from extortionate pricing to the opioid epidemic. But there’s another story to be told.

Through the story of eight revolutionary treatments, Dr William Pao cuts to the innovative heart of medical science and celebrates the tireless work of those fighting for better care. Behind each of these medicines – whether a potentially life-saving new treatment for cancer, or something as commonplace as paracetamol – there stands a cast of characters and a wealth of stories.

The trajectory from the laboratory to the local chemist is rarely a straight line. Eureka moments are few are far between. Drug hunting demands leaps of imagination and lateral thinking, the accumulation of the knowledge and expertise of many, and – nearly always – a hefty dollop of luck.

Breakthrough documents these journeys and grants a privileged look at the stories behind the medicines that improve – and very often save – our lives.